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Medisinen ble opprinnelig utviklet i Frankrike til bruk i det franske forsvaret. Den skulle brukes av det franske flyvåpenets soldater, slik at de skulle fileøle mindre tretthet og klare å konsentrere seg bedre om oppgavene sine.modafinil will reduce the extent or result of fruquintinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.

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